Chemotherapeutic Impact Of Natural Antioxidant Flavonoids (Gallic Acid, Rutin, Quercetin And Mannitol) On Pathogenic Microbes And Their Synergistic Effect

Several studies suggest that natural flavonoids with antioxidants and can influence the response to chemotherapy as well as the development of adverse side effects that results from treatment with antineoplastic agents and It‘s prevalence over Multi drug resistant bacterial strain revived interest on Flavonoids. Synergistic effect is defined as passive interaction arises when two agents combine and together, they exert an inhibitory effect that is greater than the sum of individual effect The new Synergistic therapy so that antioxidant are more effective in combination on multi drug resistant bacterial strain. Interaction between natural antioxidants and topoisomerase enzyme can be seen through Quercetin as a potent antimicrobial compound alone and in combination with other natural antioxidant like rutin. MIC/MBC result show antibacterial activity of the flavonoids were enhanced when used in combination against Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Klebsiella pneumonae, Escherichia coli as the test bacteria. The combination of rutin and quercetin, rutin and gallic acid, mannitol and gallic acid were much more effective than either flavonoid alone. Furthermore, It‘s gave a good relation between these antioxidant compound and antimicrobial activity. Flavonoids as a chemotherapeutic agent and its Synergistic effect can be solution for various microbial disease conditions.